This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson's or Alzheimer's disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.
Key topics include:
completely revised content with new contributors and new illustrations, including a full-color insertnew state-of-the-science technologiesnew areas of research and alternative model systemsup-to-date coverage of epidemiology, model systems, mechanisms of action, assessment of risk, and cellular approaches to neurotoxicologymetabolic influences on neurotoxicityrole of free radical formation in neurotoxicityinteraction between chemicals and trophic factorsendocrine disruptorsapoptosis in neurotoxicityin vivo brain imagingadvances in measuring cognitive functionadvances in developing quantitative models for neurotoxicology/risk assessment

Set on the Atlantic shore in County Mayo, Croagh Patrick is known as Ireland's Holy Mountain and attracts almost one hundred thousand pilgrims and visitors every year. In particular on Reek Sunday, the last Sunday in July, over twenty thousand people climb the mountain, some at night and some in their bare feet. Harry Hughes' book describes the pilgrimage and details the history, archaeology, ancient traditions and folklore associated with 'The Reek'. Wonderful photographs and illustrations capture the sheer beauty of the mountain and surrounding countryside, the devotion of the pilgrims, both historical and contemporary, the buildings and sacred artefacts associated with the peak and the spirit of one of Ireland's most sacred places.

Rapid advances in our understanding of basic cell biological processes and of the molecular mechanisms of cell function and dysfunction have led to an increasing interest in utilizing these approaches in neurobiological research. Efforts in the most rapidly advancing areas are multidisciplinary and the o- come of contributions from many investigators employing a variety of te- niques to address a specific problem. Although a strong basis in fundamental neurobiological concepts is essential for each researcher, the ability to apply new techniques and approaches to the examinination of both cellular and molecular processes requires knowledge of a wide variety of methodologies. The objective of Neurodegeneration Methods and Protocols is to develop an understanding, appreciation, and technical ability in various cellular and molecular techniques for studying many aspects of nervous system cell bi- ogy. The protocols in this volume span a multidisciplinary range of cellular and molecular approaches, and should allow investigators to address research questions directed toward understanding nervous system function, injury, degeneration, and the repair/regenerative process.

Chestnut Hill Local columnists Mike Todd, Janet Gilmore, Hugh Gilmore, and Jim Harris, (L-R), have not only survived in the troubled and struggling newspaper business, they have amassed a devoted following of fans who shower them with lavish presents like scrapple, bowling balls, and money from Nigerian bank accounts. Until recently, their columns were available only to the readers of the Local, but now you, too, can "LOL" as: Hugh warns of the "Enemies of Reading" Janet remembers old friends, old flames and ex-coworkers Mike deals with wrens, ferrets, and a pregnant wife in his house Jim dispenses dubious advice and rails against the system
They each have their own style and shtick, but they share a love of language and an innate ability to find the humor in everyday life. Not since Ben Franklin dined alone at the Mermaid Inn has Chestnut Hill seen such a concentration of comedic talent. Here, from among their hundreds of articles, hand-picked by a rigorous process of "One potato, two potato," is a rollicking roundup of mirthful monologues for your gracious consideration.

Rapid advances in our understanding of basic cell biological processes and of the molecular mechanisms of cell function and dysfunction have led to an increasing interest in utilizing these approaches in neurobiological research. Efforts in the most rapidly advancing areas are multidisciplinary and the o- come of contributions from many investigators employing a variety of te- niques to address a specific problem. Although a strong basis in fundamental neurobiological concepts is essential for each researcher, the ability to apply new techniques and approaches to the examinination of both cellular and molecular processes requires knowledge of a wide variety of methodologies. The objective of Neurodegeneration Methods and Protocols is to develop an understanding, appreciation, and technical ability in various cellular and molecular techniques for studying many aspects of nervous system cell bi- ogy. The protocols in this volume span a multidisciplinary range of cellular and molecular approaches, and should allow investigators to address research questions directed toward understanding nervous system function, injury, degeneration, and the repair/regenerative process.

Formality in a friendly letter subjects the other person to all the rigors of a snow storm. With those words, Joel Chandler Harris kindly admonished his six children on how to write to him while they were off at school, on prolonged visits, or working away from home. In turn, Harris kept his offspring informed about his works in progress, current events, household activities, and the latest gossip. He sternly advised his four boys--especially the oldest, Julian--on how they should conduct their lives and careers. He regaled his two daughters--his "dearest chums and partners"--with skits and sketches.

In this volume, Hugh T. Keenan has collected the 280 surviving letters--most of them never before published--written by Harris to his children. In compiling this correspondence, Keenan uses Harris's own words to "fill in the domestic autobiography for the years 1890 to 1908," offering not only an intimate portrait of the author but also a compelling glimpse of the turn-of-the-century South in which he lived. The result is the most substantial book on Harris to be published in nearly twenty-five years.

Harris's literary output during the period in which these letters were written was considerable. He produced thirteen books during the 1890s and contributed numerous short stories, essays, and articles to Scribner's and other national magazines; he was also deriving a steady income as associate editor for the "Atlanta Constitution." Living in the West End section of Atlanta, he filled his letters with fascinating details of daily life, along with insights on such famous visitors to the city as James Whitcomb Riley, William Jennings Bryan, and James O'Neill.

"Dearest Chums and Partners" also elucidates heretofore undisclosed aspects of the writer's personality and tastes, including his significant interest in the Roman Catholic Church. His French-Canadian wife, Esther LaRose Harris, was a devout Catholic, and their two daughters, Lillian and Mildred, attended convent school together. Many of the letters were mailed to the two girls at St. Joseph's Academy in Washington, Georgia. Because all incoming and outgoing mail was screened by the nuns, Harris developed a rapport with several of the sisters and wrote parts for them in skits he created for his daughters.

Letters to his sons tended to be more instructive, although he would clarify his intent: "I am not lecturing, nor issuing orders. I am merely making suggestions." He advised Julian to keep a journal and to record his "experience and observation each day, and all the incidents that occur," adding, "To do this would seem monotonous to you now, but it would be invaluable to you later."

In recording his own experiences and observations in these letters, Harris created a record of his last eighteen years that modern readers--especially those interested in the social and literary history of the South and in children's literature--will find invaluable.